Synthesis and photochemical properties of photoactivated antitumor prodrugs releasing 5-fluorouracil.

نویسندگان

  • Zhouen Zhang
  • Hiroshi Hatta
  • Takeo Ito
  • Sei-ichi Nishimoto
چکیده

A new family of antitumor prodrugs (1-3) of 5-fluorouracil (5-FU) possessing photolabile 2-nitrobenzyl chromophores have been designed and synthesized to investigate the efficiency and mechanism of photoactivated 5-FU release upon UV-irradiation at lambda(ex)= 365 nm. The photoactivated prodrug 3 derived from conjugation of 2 with a tumor-homing cyclic peptide Cys-Asn-Gly-Arg-Cys (CNGRC) was so designed as to manifest a tumor-targeting function.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 3 4  شماره 

صفحات  -

تاریخ انتشار 2005